Born in Subiaco, Papal States, daughter of Cardinal Rodrigo Borgia (later Pope Alexander VI) and Vannozza dei Cattanei.

Marries Giovanni Sforza, Lord of Pesaro and Gradara.

Marriage annulled by Pope Alexander VI on grounds of non-consummation.

Marries Alfonso of Aragon, Duke of Bisceglie and Prince of Salerno.

Alfonso of Aragon is assassinated, likely on orders of Cesare Borgia.

Marries Alfonso I d’Este, Duke of Ferrara, securing her position as Duchess of Ferrara.

Officially becomes Duchess consort of Ferrara, Modena, and Reggio.

Dies at Belriguardo Castle, Ferrara, following childbirth complications. Buried at the Convent of Corpus Domini, Ferrara.