Sinox, the first major organic chemical herbicide, was developed in France in 1896.

Sinox, the first major organic chemical herbicide, was developed in France in 1896. In the late 1940s new herbicides were developed out of the research during World War II, and the era of the “miracle” weed killers began. Within 20 years over 100 new chemicals were synthesized, developed, and put into use.

Sinox is a brand name for early organic herbicide formulations that were primarily made of sodium dinitro-o-cresylate (also known as sodium dinitrocresylate or DNOC). Developed in France in 1896, it was one of the first major selective organic chemical herbicides used for weed control in agricultural crops. ScholarsArchive@OSU ScholarsArchive@OSU +2 Key details about the composition and types of Sinox include: Active Ingredient: Sodium dinitrocresylate (or sodium 4,6-dinitro-o-cresolate). Selective Action: It was known for its ability to selectively kill broad-leaved weeds in crops like flax and peas. "Sinox General": A later, more potent version known as "Sinox General" contained dinoseb (2-sec-butyl-4,6-dinitrophenol), also known as DNOSBP, which acted as a contact herbicide. Formulations: It was commonly formulated as a liquid or powder for spraying, often used in combination with ammonium sulfate to increase effectiveness. ScholarsArchive@OSU

Note: Dinoseb-based products like Sinox General are generally banned in the United States and many other areas due to severe health hazards and risks, including birth defects and toxicity. Delaware DHSS (.gov)